They say a dog is a man’s best friend, but what if the man is a total dirtbag? In that case, it might be time for some sweet revenge, doggy style. When Reggie (Will Ferrell), a naïve, relentlessly optimistic Border Terrier, is abandoned on the mean city streets by his lowlife owner, Doug (Will Forte; The Last Man on Earth, Nebraska), Reggie is certain that his beloved owner would never leave him on purpose. But once Reggie falls in with a fast-talking, foul-mouthed Boston Terrier named Bug (Oscar® winner Jamie Foxx), a stray who loves his freedom and believes that owners are for suckers, Reggie finally realizes he was in a toxic relationship and begins to see Doug for the heartless sleazeball that he is. Determined to seek revenge, Reggie, Bug and Bug’s pals—Maggie (Isla Fisher; Now You See Me, Wedding Crashers), a smart Australian Shepherd who has been sidelined by her owner’s new puppy, and Hunter (Randall Park; Always Be My Maybe, Aquaman), an anxious Great Dane who’s stressed out by his work as an emotional support animal—together hatch a plan and embark on an epic adventure to help Reggie find his way home … and make Doug pay by biting off the appendage he loves the most. (Hint: It’s not his foot).